Molecular Details
DICL_CP_0324041
- N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0324041
PubChem CID
Molecular Formula
C16H23N5 Molecular Weight
285.395 g/mol
Synonyms/Alias
[CyPPA; 73029-73-9; N-cyclohexyl-2-(3;5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine; cyclohexyl-[2-(3;5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine; CHEMBL453730; N-cyclohexyl-2-(3;5...
InChI Key
USEMRPYUFJNFQN-UHFFFAOYSA-N
InChI
InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-...
IUPAC Name
N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine
CAS Number
73029-73-9
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
21 23 0 0 0 0 0 0 0 0999 V2000
1.5364 -4.7767 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
0.9643 -3.3901 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0
-0.5226 -3...
Experimental Data
Activity Data
Target Ion Channel
Small conductance Calcium activated potassium channel (SK2 channel)
Uniprot Accession Number
Function
Positive Allosteric Modulator
Species
Homo sapiens (Human)
IC50
N/A (Not available)
EC50
EC50: 14000 nM
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
pH 7.4
Holding Potential
−80 to 80 mV mV
Temperature
Room Temperature
Test Method
Patch-clamping
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)
Binding Information
Binding Site
Not specified
Binding Site Residue
Not specified
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
21
Rotatable Bonds
3
logP
3.3322
Complexity
83.8607
TPSA (Ų)
55.63
H-Bond Donors
1
H-Bond Acceptors
5
Ring Count
3